Production Of Transgenic Animals Notes

Transgenic animals are being used to study gene mechanism and function to adapt pig organs to be transferred to humans to prepare recombinant pharmaceutical proteins in milk and egg white and to improve breeding and food production.

Production of transgenic animals notes. Transgene is incorporated into the ES cell by Microinjection By a retro virus By electroporation Transgenic stem cells are grown in vitro. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Animals that have had their DNA manipulated to possess and express a foreign gene are known as transgenic animals.

Milk as the Medium of Protein Production. The medical and biotechnological uses of animal cloning are almost innumerable as many diseases have been eradicated thanks to the production of these transgenic animals. ES cells are obtained from the inner cell mass of a blastocyst.

The first transgenic animal was produced in 1983 when genes for human growth hormone were introduced into mice. Transgenic animal technologies have come a long way since the creation of the first transgenic mouse in 1974 Transgenic Mouse 2005. The animals used for transgenic purpose naturally carry the mechanism needed to produce complex protein.

A transgenic animal is one that carries a foreign gene that has been deliberately inserted into its genome. Applications of Genetically modified animals. The three main ways of producing transgenic animals are pronuclear manipulation embryonic stem ES cell manipulation and.

Transgenic animals produced with the purpose of producing better and good quality breed increased in milk yield as well as to produce organs to meet the demand for organ transplantation. One favoured method involves the inoculation of the DNA into the pronucleus of a fertilised ovum followed by implantation into pseudo pregnant females. Then they are inserted into a blastocyst and implanted into a hosts uterus to grow normally.

Transgenic animals are created-To study how genes are regulated and how they affect the normal functions of the body and its development. Transgenic animals have the potential of agricultural applications like improved growth rate and carcass composition improved resistance to disease increased milk. To yield industrial as well as consumer product To research human diseases To produce pharmaceutical products and tissue for implantation.